汉译英求助 敬赠2分 请版主为skyrin站友转分-2010-09-01 06:27:13 PM
William R Buras先生：你好
我有一个用神经模拟器刺激交感神经治疗肿瘤的设想。
理由如下：
1、抗癌药N-benzyladriamycin-14-alerate (AD198)通过激活protein kinase C-delta导致癌细胞凋亡，体外实验和体内实验证实N-benzyladriamycin-14-alerate (AD198)具有比阿霉素更好的抗癌作用（1.2.3）。研究发现N-benzyladriamycin-14-alerate (AD198)对topoisomerase II的抑制作用很弱,和DNA的结合也很弱，研究证实N-benzyladriamycin-14-alerate (AD198)通过结合deltaC1b domain 进而激活PKC-delta（4.5.6）。
2、研究发现PKC-a激活K-Ras 后导致癌细胞凋亡（7）。
3、cAMP以及cAMP类似物8--Br--cAMP、8--Cl--cAMP对很多癌细胞具有分化诱导作用。
4、研究发现肿瘤里含有神经组织（8.9）
交感神经释放的神经递质去甲肾上腺素和细胞a1受体和B受体作用后能激活PKC-a和PKC-delta，也能激活腺苷酸环化酶，促进cAMP的产生。
因此，理论上刺激交感神经存在治疗和杀死肿瘤的可能性和可行性。
比如，肝癌，就用神经模拟器刺激支配肝脏的交感神经治疗肝肿瘤。
参考文献如下：
Dear Sir William R Buras:
How is erything going?
I got a idea to stimulate sympathetic neres for the treatment of tumor by the nere stimulator.
The reasons are as follows:
1 N-benzyladriamycin-14-alerate(AD198) is a kind of anti-cancer drug, which causes apoptosis of the cancer cell by actiating the protein kinase C-delta. It is confirmed by the in itro and in io experiments that the N-benzyladriamycin-14-alerate(AD198) has better anti-cancer effect than adriamycin(1.2.3). The researches hae found that the N-benzyladriamycin-14-alerate(AD198) has ery weak inhibition of topoisomerase II, and also is not easy to combine the DNA. The Researches hae proen that the N-benzyladriamycin-14-alerate(AD198) actiates PKC-delta(4.5.6) by the combination of deltaC 1 b, the domain .
2 Preious studies hae discoered that the PKC-a causes the apoptosis of cancer cell by actiating the K-Ras(7).
3 The cAMP and the cAMP similar substances such as 8-Br-cAMP, 8-the Cl-cAMP hae the induction and differentiation effect of a lot of cancer cells.
4 Preious studies hae discoered there is nerous tissue in the tumor(8.9).
Noradrenalin ,which is released from the sympathetic neres , combines a1 and B receptors, then actiates PKC-a and PKC-delta, and also can actiate the adenylate cyclase, and then promote the creation of cAMP .
Therefore, It is theoretically conceiable and feasible to treat and kill the the tumor by stimulating sympathetic neres.
For example, we can treat the lier tumor by using the nere stimulator to stimulate the sympathetic neres of the lier.
Reference is as follows:
I hae a tentatie idea about a possible cancer therapy by stimulation of sympathetic nere with a nere simulator.
Here below the basis for this idea are proided,
1.Anticarcinogen N-benzyladriamycin-14-alerate (AD198) can induce apoptosis by actiation of protein kinase C-delta. Many studies in io and in itro hae already proed that N-benzyladriamycin-14-alerate (AD198) hae a better antitumous effect than adriamycin. Some study showed that N-benzyladriamycin-14-alerate (AD198) hae a weak inhibition effect on topoisomerase II and hae a weak binding to DNA. N-benzyladriamycin-14-alerate (AD198) can actiate PKC-delta following by its binding to deltaC1b domain.
2.Some studies showed that PKC-a induce the apoptosis following by its actiation of K-Ras.
3.cAMP and its analogues 8--Br--cAMP、8--Cl—cAMP can induced differentiation of many kinds of cancer cells.
4.It was reported that nerous tissue are found in tumors.
The neurotransmitter noradrenalin releaseed from sympathetic nere endings can actiate PKC-a and PKC-delta by its interaction with a1 and B receptors, as well as production of cAMP following by actiation of adenylcyclase.
Therefore, it’s theoretically possible and feasible to treat cancer and kill cancer cells by stimulation of sympathetic nere.
For instance, hepatoma was treated by the stimulation of the sympathetic nere which innerated lier by nere simulator.
reference are as follows,
I hae a tentatie idea about a possible cancer therapy by stimulation of sympathetic nere with a nere simulator.
Here below the basis for this idea are proided,
1.Anticarcinogen N-benzyladriamycin-14-alerate (AD198) can induce apoptosis by actiation of protein kinase C-delta. Many studies in io and in itro hae already proed that N-benzyladriamycin-14-alerate (AD198) hae a better antitumous effect than adriamycin. Some study showed that N-benzyladriamycin-14-alerate (AD198) hae a weak inhibition effect on topoisomerase II and hae a weak binding to DNA. N-benzyladriamycin-14-alerate (AD198) can actiate PKC-delta following by its binding to deltaC1b domain.
2.Some studies showed that PKC-a induce the apoptosis following by its actiation of K-Ras.
3.cAMP and its analogues 8--Br--cAMP、8--Cl—cAMP can induced differentiation of many kinds of cancer cells.
4.It was reported that nerous tissue are found in tumors.
The neurotransmitter noradrenalin releaseed from sympathetic nere endings can actiate PKC-a and PKC-delta by its interaction with a1 and B receptors, as while as production of cAMP following by actiation of adenylcyclase.
Therefore, it’s theoretically possible and feasible to treat cancer and kill cancer cells by stimulation of sympathetic nere.
For instance, hepatoma was treated by the stimulation of the sympathetic nere which innerated lier by nere simulator.
reference are as follows,
I hae a tentatie idea about a possible cancer therapy by stimulation of sympathetic nere with a nere simulator.
Here below the basis for this idea are proided,
1.Anticarcinogen N-benzyladriamycin-14-alerate (AD198) can induce apoptosis by actiation of protein kinase C-delta. Many studies in io and in itro hae already proed that N-benzyladriamycin-14-alerate (AD198) hae a better antitumous effect than adriamycin. Some study showed that N-benzyladriamycin-14-alerate (AD198) hae a weak inhibition effect on topoisomerase II and hae a weak binding to DNA. N-benzyladriamycin-14-alerate (AD198) can actiate PKC-delta following by its binding to deltaC1b domain.
2.Some studies showed that PKC-a induce the apoptosis following by its actiation of K-Ras.
3.cAMP and its analogues 8--Br--cAMP、8--Cl—cAMP can induced differentiation of many kinds of cancer cells.
4.It was reported that nerous tissue are found in tumors.
The neurotransmitter noradrenalin releaseed from sympathetic nere endings can actiate PKC-a and PKC-delta by its interaction with a1 and B receptors, as while as production of cAMP following by actiation of adenylcyclase.
Therefore, it’s theoretically possible and feasible to treat cancer and kill cancer cells by stimulation of sympathetic nere.
For instance, hepatoma was treated by the stimulation of the sympathetic nere which innerated lier by nere simulator.
reference are as follows,
发表者QINQIN 时间 2010-09-01 06:27:13 PM
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