【文摘发布】急性排斥反应的发生不依赖于热休克蛋白－70的诱导

【文摘发布】急性排斥反应的发生不依赖于热休克蛋白－70的诱导

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Title：Acute allograft rejection occurs independently of inducible heat shock protein-70.
Authors：Tesar BM, Goldstein DR.
Source：transplantaiton，2007 Jun 15;83(11):1513-7
Abstract：Dendritic cells (DCs) are key mediators of the innate response to transplantation. Yet, the substances that actiate these cells during acute allograft rejection remain elusie. Preious work has suggested that heat shock protein (HSP)-70 is associated with acute allograft rejection. Hence, the goal of this study was to determine whether HSP-70 actiates DCs and plays a critical role in acute allograft rejection in an experimental model that is dependent on innate MyD88 signaling. Our in itro data indicate that HSP-70 does not actiate DCs. In io transplant studies demonstrate that HSP-70 leels are not increased during acute allograft rejection and that an absence of the inducible form of HSP-70 neither delays acute allograft rejection, impairs DCs maturation, nor alters Th1 immune responses during acute allograft rejection. In conclusion, our results indicate that HSP-70 in our experimental models does not play an essential role in acute allograft rejection.

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Acute allograft rejection occurs independently of inducible heat shock protein-70.
急性排斥反应的发生不依赖热休克蛋白-70的诱导

Dendritic cells (DCs) are key mediators of the innate response to transplantation. Yet, the substances that actiate these cells during acute allograft rejection remain elusie.
树突状细胞（DCs）是移植免疫应答反应的关键始动者。然而，在急性同种异体排斥中DCs细胞活化的本质尚不十分明了。

Preious work has suggested that heat shock protein (HSP)-70 is associated with acute allograft rejection.
先前的工作表明热休克蛋白（HSP）-70与急性同种异体排斥反应相关。

Hence, the goal of this study was to determine whether HSP-70 actiates DCs and plays a critical role in acute allograft rejection in an experimental model that is dependent on innate MyD88 signaling. Our in itro data indicate that HSP-70 does not actiate DCs.
因此，本研究目的是在依赖MyD88信号途径的实验模型中，确定HSP-70是否激活DCs细胞，是否在急性同种异体排斥反应中起关键作用。体外实验显示HSP-70并没有激活DCs。

In io transplant studies demonstrate that HSP-70 leels are not increased during acute allograft rejection and that an absence of the inducible form of HSP-70 neither delays acute allograft rejection, impairs DCs maturation, nor alters Th1 immune responses during acute allograft rejection.
体内移植研究发现：在发生急性同种异体排斥反应时，HSP-70水平并没有增加；缺少HSP-70诱导剂时既没有延迟急性同种异体排斥反应的发生和影响DCs的成熟，也没有改变Th1细胞的免疫应答反应。

In conclusion, our results indicate that HSP-70 in our experimental models does not play an essential role in acute allograft rejection.
总之，我们的结果表明在实验模型中，HSP-70没有对急性同种异体排斥反应发挥重要的作用。

编译：

急性排斥反应的发生不依赖热休克蛋白-70的诱导

树突状细胞（DCs）是移植免疫应答反应的关键始动者。然而，在急性同种异体排斥中DCs细胞活化的机制尚不十分明了。先前的工作表明热休克蛋白（HSP）-70与急性同种异体排斥反应相关。因此，本研究目的是在依赖MyD88信号途径的实验模型中，确定HSP-70是否激活DCs细胞，是否在急性同种异体排斥反应中起关键作用。体外实验显示HSP-70并没有激活DCs；体内移植研究发现：在发生急性同种异体排斥反应时，HSP-70水平并没有增加；缺少HSP-70诱导剂时既没有延迟急性同种异体排斥反应的发生和影响DCs的成熟，也没有改变Th1细胞的免疫应答反应。总之，我们的结果表明在实验模型中，HSP-70没有对急性同种异体排斥反应发挥重要的作用。